Program Results

Introduction to the event

In the first year of the project, we successfully established the laboratory and conducted a systematic analysis of 232 yeast proteins that translocate to the lysosome/vacuole under metabolic stress. This screen revealed that specific plasma membrane transporters and lipid droplet–associated proteins are selectively targeted to the vacuole during stress. Furthermore, by employing a panel of 112 knockout strains deficient in ubiquitin ligases or deubiquitinases, we identified several key genes that critically influence this targeting process. These results provide a strong foundation for the next phase of the project, which will focus on dissecting the regulatory pathways underlying vacuolar trafficking during metabolic stress.

In parallel with research activities, Dr. Lee contributed to academic community building by co-organizing the 63rd Annual Meeting of the Agricultural Chemical Society of Taiwan, supported by the NSTC Life Sciences Research Promotion Center grant. The meeting featured the thematic seminar “Exploring the Lipids of Life — Conference on Lipid Metabolism and Metabolic Diseases”, held on June 25 at National Taiwan University. This event brought together leading lipid metabolism researchers from across Taiwan, creating an important platform for scientific exchange and collaboration in a field where domestic expertise is still emerging.

Photos from the event: Exploring the Lipids of Life — Conference on Lipid Metabolism and Metabolic Diseases